eliquis.bmscustomerconnect.comHow Rx ELIQUIS® (apixaban) Can Help | Safety Info

This website is best viewed using the vertical display on your mobile device. This website is best viewed using the horizontal display on your tablet device. U.S. Full Prescribing Information Including Boxed WARNINGS Medication Guide Indications Healthcare Professionals Site En Español Menu INDICATIONS ELIQUIS (apixaban) is a prescription medicine used to reduce the risk of stroke and blood clots in people who have atrial fibrillation (AFib), a type of irregular heartbeat, not caused by a heart valve problem. ELIQUIS (apixaban) is a prescription medicine used to treat blood clots in the veins of your legs (deep vein thrombosis) or lungs (pulmonary embolism), and reduce the risk of them occurring again. ELIQUIS (apixaban) is a prescription medicine used to reduce the risk of forming a blood clot in the legs and lungs of people who have just had hip or knee replacement surgery. 1 2 3 This site is intended for U.S. residents 18 years of age or older. Healthcare Professionals Site En Español See Indications This site is intended for U.S. residents 18 years of age or older. Call Us at 1-855-ELIQUIS Activate Co-pay Card Tell Me How ELIQUIS Can Help Reduce the Risk of Stroke Due to Nonvalvular Atrial Fibrillation (AFib) ELIQUIS & Nonvalvular AFib For patients with AFib, a type of irregular heartbeat, not caused by a heart valve problem Treat Blood Clots In the Veins of the Legs/Lungs & Reduce Risk of it Occurring Again ELIQUIS & DVT/PE For patients with deep vein thrombosis (DVT) or pulmonary embolism (PE) Decrease Risk of DVT Blood Clots After Hip or Knee Replacement Surgery ELIQUIS & Hip/Knee Replacement For patients who have had hip or knee replacement surgery − Click to Collapse Important facts about ELIQUIS ® (apixaban) This is a summary of important safety information that you need to know about ELIQUIS. Look out for the following icons as you read: Talk to your healthcare team Call a healthcare provider right away Helpful information to remember Do not stop taking ELIQUIS without talking to the doctor who prescribed it to you For patients taking ELIQUIS for atrial fibrillation: stopping ELIQUIS increases your risk of having a stroke. Talk to your healthcare team before any medical procedures. ELIQUIS may need to be stopped before surgery or a medical or dental procedure. Your doctor will tell you when you should stop taking ELIQUIS and when you may start taking it again. If you have to stop taking ELIQUIS, your doctor may prescribe another medicine to help prevent a blood clot from forming. What are the possible serious side effects of ELIQUIS? This is a list of some of the serious side effects of ELIQUIS. Bleeding ELIQUIS can cause bleeding, which can be serious, and rarely may lead to death. This is because ELIQUIS is a blood thinner medicine that reduces blood clotting. While taking ELIQUIS, you may bruise more easily and it may take longer than usual for any bleeding to stop. You may have a higher risk of bleeding if you take ELIQUIS with other medicines that increase your risk of bleeding, such as: Aspirin Nonsteroidal anti-inflammatory drugs (called NSAIDs) Warfarin ® ) Heparin Selective serotonin reuptake inhibitors (SSRIs) or serotonin norepinephrine reuptake inhibitors (SNRIs) Other medicines to help prevent or treat blood clots Tell your doctor if you take any of these medicines. Call your doctor or get medical help right away if you have any of these signs or symptoms of bleeding when taking ELIQUIS: Unexpected bleeding or bleeding that lasts a long time, such as: Unusual bleeding from the gums Nosebleeds that happen often Menstrual or vaginal bleeding that is heavier than normal Bleeding that is severe or you cannot control Red, pink, or brown urine Red or black stools (looks like tar) Coughing up or vomiting blood Vomit that looks like coffee grounds Unexpected pain, swelling, or joint pain Headaches Feeling dizzy or weak Spinal or epidural blood clots (hematoma) People who take ELIQUIS, and have medicine injected into their spinal or epidural area, or have a spinal puncture, have a risk of forming a blood clot that can cause long-term or permanent loss of the ability to move (paralysis). Your risk of developing a spinal or epidural blood clot is higher if: A thin tube called an epidural catheter is placed in your back to give you certain medicine You take NSAIDs or a medicine to prevent blood from clotting You have a history of difficult or repeated epidural or spinal punctures You have a history of problems with your spine or have had surgery on your spine If you take ELIQUIS and receive spinal anesthesia or have a spinal puncture, your doctor should watch you closely for symptoms of spinal or epidural blood clots or bleeding. Tell your doctor right away if you have any of these signs or symptoms (especially in your legs and feet) when taking ELIQUIS: Tingling Numbness Muscle weakness A reaction to ELIQUIS itself A reaction to ELIQUIS can cause hives, rash, itching, and possibly trouble breathing. If you get this reaction, it will usually happen soon after you take a dose of ELIQUIS. Get medical help right away if you have any of the following symptoms: Sudden chest pain or chest tightness Sudden swelling of your face or tongue Trouble breathing Wheezing Feeling dizzy or faint Talk to your doctor about any side effect that may be bothering you or that does not go away. These are not all of the possible side effects of ELIQUIS. Call your doctor for medical advice about side effects. You are encouraged to report any side effects to the FDA at 1-800-FDA-1088. 1-800-FDA-1088 . Who should not take ELIQUIS? ELIQUIS is not for patients who: have artificial heart valves have antiphospholipid syndrome (APS), especially with positive triple antibody testing, who have a history of blood clots currently have certain types of abnormal bleeding have had a serious allergic reaction to ELIQUIS What should I discuss with my healthcare team before starting ELIQUIS? Talk to your healthcare team about the following: Kidney or liver problems If you have antiphospholipid syndrome Any other medical conditions If you have ever had bleeding problems Talk to your doctor about your risk of severe uterine bleeding if you are treated with ELIQUIS.Tell your doctor if you are pregnant or breastfeeding, or planning to become pregnant or breastfeed. You and your doctor should decide if you will take ELIQUIS or breastfeed. You should not do both. Females who are able to become pregnant: talk with your healthcare provider about pregnancy planning, and your risk of severe uterine bleeding if you are treated with blood thinner medicines, including ELIQUIS. Tell your healthcare team about all the medicines you take, including any: prescription medicines over-the-counter medicines vitamins herbal supplements During treatment, make sure you talk to your healthcare team before you begin to take any new medication. How should I take ELIQUIS? Take ELIQUIS exactly as prescribed by your doctor. Twice daily With or without food Do not change your dose or stop taking ELIQUIS unless your doctor tells you to. What if I miss a dose of ELIQUIS? If you miss a dose of ELIQUIS, take it as soon as you remember, and do not take more than one dose at the same time. When should I refill my prescription? If you are taking ELIQUIS for atrial fibrillation, stopping ELIQUIS may increase your risk of having a stroke. Do not run out of ELIQUIS. Refill your prescription before you run out. When leaving the hospital following hip or knee replacement, be sure that you will have ELIQUIS available to avoid missing any doses. ELIQUIS is available in two different tablets. Your doctor or healthcare provider will determine what dose is right for you. 2.5 mg tablet Round, with a pale yellow color OR 5 mg tablet Oval, with a pale orange or pink color Note: Images do not represent actual tablet size. On one side of each tablet, there is a number indicating the dosage strength of the tablet (in...